On Development of Some Soft Computing Based Multiuser Detection Techniques for SDMA–OFDM Wireless Communication System

Space Division Multiple Access(SDMA) based technique as a subclass of Multiple Input Multiple Output (MIMO) systems achieves high spectral efficiency through bandwidth reuse by multiple users. On the other hand, Orthogonal Frequency Division Multiplexing (OFDM) mitigates the impairments of the propagation channel. The combination of SDMA and OFDM has emerged as a most competitive technology for future wireless communication system. In the SDMA uplink, multiple users communicate simultaneously with a multiple antenna Base Station (BS) sharing the same frequency band by exploring their unique user specific-special spatial signature. Different Multiuser Detection (MUD) schemes have been proposed at the BS receiver to identify users correctly by mitigating the multiuser interference. However, most of the classical MUDs fail to separate the users signals in the over load scenario, where the number of users exceed the number of receiving antennas. On the other hand, due to exhaustive search mechanism, the optimal Maximum Likelihood (ML) detector is limited by high computational complexity, which increases exponentially with increasing number of simultaneous users. Hence, cost function minimization based Minimum Error Rate (MER) detectors are preferred, which basically minimize the probability of error by iteratively updating receiver’s weights using adaptive algorithms such as Steepest Descent (SD), Conjugate Gradient (CG) etc. The first part of research proposes Optimization Techniques (OTs) aided MER detectors to overcome the shortfalls of the CG based MER detectors. Popular metaheuristic search algorithms like Adaptive Genetic Algorithm (AGA), Adaptive Differential Evolution Algorithm (ADEA) and Invasive Weed Optimization (IWO), which rely on an intelligent search of a large but finite solution space using statistical methods, have been applied for finding the optimal weight vectors for MER MUD. Further, it is observed in an overload SDMA–OFDM system that the channel output phasor constellation often becomes linearly non-separable. With increasing the number of users, the receiver weight optimization task turns out to be more difficult due to the exponentially increased number of dimensions of the weight matrix. As a result, MUD becomes a challenging multidimensional optimization problem. Therefore, signal classification requires a nonlinear solution. Considering this, the second part of research work suggests Artificial Neural Network (ANN) based MUDs on thestandard Multilayer Perceptron (MLP) and Radial Basis Function (RBF) frameworks fo

Structural Analysis of Nano Core PCF With Fused Cladding for Supercontinuum Generation in 6G Networks

The Sixth Generation (6G) networks have identified the use of frequency range between 95 GHz and 3 THz with a targeted data rate of 1 Terabytes/second at the access network for holographic video applications. As is demands broadening of spectrum at the core network, this paper proposes a Supercontinuum Generation (SCG) through photonic crystal fiber (PCF) as it provides excellent broadening of the optical spectrum. Discussed in the paper is supercontinuum generation at high pumping power as per the standards specified by the International Telecommunications Union. The proposed PCF is designed with silicon nanocrystal core and the cladding microstructures is arranged in a fusion approach to effectively optimize the optical parameters such as dispersion, nonlinearity, birefringence, group-velocity dispersion, and confinement loss. The fused cladding comprises of a flower-cladding assembly in which air-holes arrangement is inspired from petals in a pleated structure. Such arrangement is shown here to provide high nonlinearity and negative dispersion for high power supercontinuum generation. The novel nanocore assembly with improved structural constraints delivers a non-linearity of 6.37 × 106 W−1 km−1 and a negative dispersion of −142.1 (ps/nm-km) at 1,550 nm. Moreover, a supercontinuum spectrum is generated using different pulse widths ranging from 350 to 650 ps with 25 kW pump power for PCF lengths of 10 and 15 mm

Putative tumour-suppressor gene DAB2 is frequently down regulated by promoter hypermethylation in nasopharyngeal carcinoma

<p>Abstract</p> <p>Background</p> <p>Human Disabled-2 (DAB2), is a multi-function signalling molecule that it is frequently down-regulated in human cancers. We aimed to investigate the possible tumour suppressor effect of DAB2 in nasopharyngeal carcinoma (NPC).</p> <p>Methods</p> <p>We studied the expression of DAB2 in NPC cell lines, xenografts and primary tumour samples. The status of promoter methylation was assessed by methylation specific PCR and bisulfite sequencing. The functional role of DAB2 in NPC was investigated by re-introducing DAB2 expression into NPC cell line C666-1.</p> <p>Results</p> <p>Decrease or absent of <it>DAB2 </it>transcript was observed in NPC cell lines and xenografts. Loss of DAB2 protein expression was seen in 72% (33/46) of primary NPC as demonstrated by immunohistochemistry. Aberrant <it>DAB2 </it>promoter methylation was detected in 65.2% (30/46) of primary NPC samples by methylation specific PCR. Treatment of the DAB2 negative NPC cell line C666-1 with 5-aza-2'-deoxycytidine resulted in restoration of DAB2 expression in a dose-dependent manner. Overexpression of DAB2 in NPC cell line C666-1 resulted in reduced growth rate and 35% reduction in anchorage-dependent colony formation, and inhibition of serum-induced c-Fos expression compared to vector-transfected controls. Over expression of DAB2 resulted in alterations of multiple pathways as demonstrated by expression profiling and functional network analysis, which confirmed the role of DAB2 as an adaptor molecule involved in multiple receptor-mediated signalling pathways.</p> <p>Conclusions</p> <p>We report the frequent down regulation of DAB2 in NPC and the promoter hypermethylation contributes to the loss of expression of DAB2. This is the first study demonstrating frequent DAB2 promoter hypermethylation in human cancer. Our functional studies support the putative tumour suppressor effect of DAB2 in NPC cells.</p

Intelligent Energy Management for Distributed Power Plants and Battery Storage

A smart energy management controller is required for effective source coordination and load demand management. This work proposes a novel instantaneous current reference technique for use in power management of hybrid power systems (HPS), both autonomous and interconnected with the grid. A grid integrated hybrid power system (GI-HPS) includes both the AC grid and additional sources used in industrial and commercial environments. Solar photovoltaic (SPV) panels, wind turbine generators, proton exchange membrane fuel cells, and batteries are all part of the test system. The suggested energy management system (SEMS) manages power from the hybrid power source and the energy storage components to meet the load needs. The recommended SEMS can transit between 12 different modes of operation to fulfil the load demand requirements. The SEMS employs a scaling factor N to accelerate the rate at which the measured current approaches the reference current. The proposed scaling factor significantly improves the SEMS’s dynamic performance since it can quickly respond to the changes in the source and load characteristics. The dependability of an HPS powered by a variety of renewable energy sources can also be improved